9 Signs and Symptoms of Vitamin B12 Deficiency

9 Signs and Symptoms of Vitamin B12 Deficiency

Have you ever experienced inexplicable fatigue and weakness, combined numbness and tingling in the hands and feet, difficulty walking or balance problems, difficulty thinking, or memory loss? These are just a few potential signs and symptoms of vitamin B12 deficiency. Various factors, including gastrointestinal disorders, aging, certain medications, and smoking, can cause vitamin B12 deficiency. 

This article will explore the intricacies of vitamin B12, its role in the body, and the nine most common signs and symptoms of vitamin B12 deficiency. 

You can take steps to prevent long-term complications and maintain your overall health and well-being by understanding the importance of proper nutrition and recognizing the warning signs of vitamin B12 deficiency. So, let’s dive into the complex world of vitamin B12 and explore its fascinating properties and potential impact on your health.

What is Vitamin B12?

Vitamin B12 – sometimes called cobalamin – is a water-soluble vitamin playing a critical role in the body’s metabolic processes, including DNA synthesis, red blood cell production, and the proper functioning of the nervous system. The chemical structure of vitamin B12 is unique among vitamins, containing a cobalt atom surrounded by a corrin ring and a variable side chain.

Naturally derived from animal products such as meat, fish, and dairy, vitamin B12 is essential for human health and cannot be produced by the body.

Although rare, severe deficiency of vitamin B12 can result in various serious health problems, including anemia, neuropathy, and cognitive impairment. Inadequate intake of vitamin B12 is a common problem, particularly among specific populations such as vegans and vegetarians, as well as older adults and those with gastrointestinal disorders.

9 Signs and Symptoms of Vitamin B12 Deficiency

Vitamin B12 deficiency can manifest in many symptoms, including fatigue, weakness, numbness, tingling in the hands and feet, and difficulty walking or maintaining balance. The symptoms of vitamin B12 deficiency can vary widely in severity, with some individuals experiencing mild or vague symptoms while others may develop more severe or life-threatening complications.

  1. Fatigue and weakness: Fatigue and weakness are two of the most prevalent signs of vitamin B12 deficiency. Because vitamin B12 produces red blood cells, lacking this essential nutrient prevents oxygen from reaching the body’s tissues. As a result, individuals with vitamin B12 deficiency may experience persistent fatigue and weakness, even after getting adequate rest and sleep.
  2. Numbness and tingling in the hands and feet: Combined numbness and tingling in the hands and feet are also common signs of vitamin B12 deficiency. This symptom happens because vitamin B12 is essential for proper nervous system function, and a lack of this nutrient can result in nerve damage or dysfunction.
  3. Difficulty walking or balance problems: Vitamin B12 is crucial in forming and maintaining the myelin sheath surrounding and protecting nerve fibers. In some cases, nerve damage caused by vitamin B12 deficiency can affect the parts of the nervous system that control movement and balance. The damage can result in difficulty walking or an unsteady gait, increasing the risk of falls and other accidents.
  4. Pale or jaundiced skin: Without adequate vitamin B12, the body may produce fewer red blood cells, or the red blood cells may not function properly, leading to anemia. The breakdown of red blood cells can lead to an increase in bilirubin, a waste product that gives urine its yellow color and can also cause yellowing of the skin and whites of the eyes (jaundice).
  5. Smooth or swollen tongue: Vitamin B12 is essential for maintaining the tongue’s health, and a deficiency can lead to various oral symptoms. In addition to a smooth or swollen appearance, other symptoms of vitamin B12 deficiency-related tongue issues may include soreness, redness, or a burning sensation. Sometimes, the tongue may also become abnormally pale or yellowish.
  6. Difficulty thinking or memory loss: Damaged myelin sheath due to vitamin B12 deficiency can lead to various neurological symptoms. These may include difficulty concentrating, brain fog, forgetfulness, confusion, and dementia-like symptoms.
  7. Mood changes or depression: Besides neurological symptoms, vitamin B12 deficiency can lead to psychological symptoms, such as depression, anxiety, and irritability. Vitamin B12 plays a central role in the body’s serotonin production, a neurotransmitter that regulates mood and emotions. When vitamin B12 levels are low, serotonin production can be affected, leading to psychological symptoms such as depression, anxiety, irritability, and even psychosis.
  8. Vision loss: When vitamin B12 levels are low, the optic nerve can become damaged, leading to various visual symptoms, such as blurred or double vision, light sensitivity, and even vision loss in severe cases.
  9. Mouth Ulcers: Vitamin B12 plays a role in the health and maintenance of the oral mucosa, which is the mouth’s and throat’s protective lining. When vitamin B12 levels are low, the oral mucosa can become damaged or inflamed, leading to painful, recurrent mouth ulcers.

While the symptoms of vitamin B12 deficiency can often be effectively managed with appropriate treatment, failure to address the underlying shortage can lead to severe and potentially irreversible complications. Treatment for vitamin B12 deficiency typically involves oral or intramuscular supplementation, identifying and addressing any underlying conditions contributing to the deficit, and using intravenous (IV) therapy to bypass the digestion system.

Prevention of Vitamin B12 Deficiency

Intravenous (IV) therapy can be an effective way to prevent and treat vitamin B12 deficiency. IV therapy delivers the vitamin directly into the bloodstream, bypassing the digestive system and ensuring maximum absorption, delivering sure and quick results.

IV therapy can be especially beneficial for individuals who struggle to absorb vitamin B12 from food or supplements due to pernicious anemia, Crohn’s disease, celiac disease, or those who have undergone gastrointestinal surgery.


If you are experiencing vitamin B12 deficiency symptoms or are at risk for this condition, consider speaking with High Country Infusion & Wellness Center about the benefits of intravenous (IV) therapy. You can talk to us by phone at (970) 446-5191 or support@highcountryinfusion.com. With the right education, proper care, and proven treatment, you can address your vitamin B12 deficiency and improve your overall health and well-being.


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